Reagent-free aerobic oxidative synthesis of amides from aldehydes and isothiocyanates

Abstract

An efficient and facile method for the synthesis of amides from aldehydes with isothiocyanates under reagent-free autoxidative conditions is established. This protocol showcases the capture of carboxylic acids in situ generated through aldehyde autoxidation by isothiocyanates as both coupling mediators and amine surrogates, featuring no use of catalysts, explosive chemical oxidants, and additional activating reagents.