Issue 4, 2021

Sensitive and specific detection of peroxynitrite and in vivo imaging of inflammation by a “simple” AIE bioprobe

Abstract

A luminogenic bioprobe TPE-DMAB for simple and specific detection of peroxynitrite (ONOO) has been developed. TPE-DMAB exhibits aggregation-induced emission (AIE) characteristic and shows fluorescence enhancement (up to 100-fold) upon cleavage of phenylboronic moieties by ONOO. TPE-DMAB can be facilely synthesized and displays excellent specificity and sensitivity towards ONOO (detection limit of 54 nM). Based on these novel properties of TPE-DMAB, we further produced its encapsulated nanoparticles and successfully used them to detect endogenous ONOO in macrophage cells and visualize the inflammation sites of mice, verifying the great potential of TPE-DMAB for biological applications.

Graphical abstract: Sensitive and specific detection of peroxynitrite and in vivo imaging of inflammation by a “simple” AIE bioprobe

Supplementary files

Article information

Article type
Research Article
Submitted
30 Nov 2020
Accepted
31 Dec 2020
First published
05 Jan 2021

Mater. Chem. Front., 2021,5, 1830-1835

Sensitive and specific detection of peroxynitrite and in vivo imaging of inflammation by a “simple” AIE bioprobe

H. Xie, J. Zhang, C. Chen, F. Sun, H. Liu, X. He, K. W. K. Lam, Z. Li, J. W. Y. Lam, G. Zhang, D. Ding, R. T. K. Kwok and B. Z. Tang, Mater. Chem. Front., 2021, 5, 1830 DOI: 10.1039/D0QM01004A

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