Recent progress in the applications of amino–yne click chemistry

Abstract

Click chemistry has been rapidly developed in recent years. Among various established click reaction systems, the spontaneous amino–yne click reaction stands out. In addition to the general advantages associated with click reactions, amino–yne click reaction possesses extra merits, such as spontaneity of reactions, ubiquity of amines and cleavability of products with specific stimuli. Therefore, the amino–yne click reaction has become a useful tool and provided convenience for scientists in various fields since its first report in 2017. In this review, we capture the recent progress in the applications of amino–yne click reaction, which are briefly classified and reviewed in the fields of surface immobilization, drug delivery carrier design, hydrogel materials preparation and synthesis of polymers with unique structures.