Jump to main content
Jump to site search

Issue 1, 2021

Ultra-thin patchy polymer-coated graphene oxide as a novel anticancer drug carrier

Author affiliations

Abstract

An ultra-thin, graphene oxide (GO) based, anticancer drug carrier was developed using Reversible Addition Fragmentation chain Transfer (RAFT) mediated emulsion polymerisation. Short chain macro-RAFT copolymer, BuPATTC-(BA4-stat-AA9-stat-StS5), was used to disperse the GO in water. Subsequent free radical emulsion polymerisation produced an aqueous suspension of partially polymer-coated GO (PPC-GO). The polymer coating was unevenly distributed, forming a patchy and extremely rough surface on the GO substrate. The use of macro-RAFT copolymers greatly improved the overall colloidal stability of the GO. Furthermore, particle morphologies were found to be controllable by adjusting the amount of monomer starve fed into the polymerisation. PPC-GO was demonstrated to be an effective carrier for the anti-cancer drug doxorubicin (Dox), storing equivalent to its own original weight in Dox. A releasing mechanism using L-ascorbic acid (L-AA) as an agent was reported. Dox release can be triggered by chemical reduction using L-AA, which weakens the hydrogen bonds between Dox and GO. After release of the Dox, the remaining PPC- reduced GO (PPC-rGO) was found to be stable in aqueous suspension.

Graphical abstract: Ultra-thin patchy polymer-coated graphene oxide as a novel anticancer drug carrier

Supplementary files

Article information


Submitted
27 May 2020
Accepted
15 Jul 2020
First published
22 Jul 2020

Polym. Chem., 2021,12, 92-104
Article type
Paper

Ultra-thin patchy polymer-coated graphene oxide as a novel anticancer drug carrier

V. T. Huynh, D. Nguyen, L. Zhu, N. T. H. Pham, P. Priyananda and B. S. Hawkett, Polym. Chem., 2021, 12, 92 DOI: 10.1039/D0PY00769B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements