Palladium-catalyzed and alcohol-enabled transformation to synthesize benzocyclic ketones

Abstract

Catalytic carbonyl formation ranks as one of the most important synthetic methodologies. Herein, a highly effective palladium-catalyzed and alcohol-promoted transformation of nitriles to synthesize benzocyclic ketones is described. It provides a straightforward access to potentially valuable indanone compounds in high yields in the presence of alcohol. It avoided the usage of carbon monoxide or an additional hydrolysis procedure.