Issue 44, 2021

Alkylation of quinoxalin-2(1H)-ones using phosphonium ylides as alkylating reagents

Abstract

A practical and efficient methodology for the construction of 3-alkylquinoxalinones through base promoted direct alkylation of quinoxalin-2(1H)-ones with phosphonium ylides as alkylating reagents under metal- and oxidant-free conditions was developed. Various 3-alkylquinoxalin-2(1H)-ones were easily obtained in good to excellent yields. Tentative mechanistic studies suggest that this reaction is likely to involve a nucleophilic addition–elimination process.

Graphical abstract: Alkylation of quinoxalin-2(1H)-ones using phosphonium ylides as alkylating reagents

Supplementary files

Article information

Article type
Paper
Submitted
19 Sep 2021
Accepted
26 Oct 2021
First published
29 Oct 2021

Org. Biomol. Chem., 2021,19, 9705-9710

Alkylation of quinoxalin-2(1H)-ones using phosphonium ylides as alkylating reagents

S. Peng, J. Liu and L. Yang, Org. Biomol. Chem., 2021, 19, 9705 DOI: 10.1039/D1OB01858B

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