Issue 39, 2021

Pd-Catalyzed solvent-controlled site-selective arene C–H monoacyloxylation of pyrrolo[2,3-d]pyrimidine derivatives

Abstract

An efficient and highly regioselective Pd-catalyzed direct arene C(sp2)–H acyloxylation of pyrrolo[2,3-d]pyrimidine derivatives is reported. The key strategy involves the utilization of the unique reactivity of pyrrolo[2,3-d]pyrimidine and the employment of pyrrolo[2,3-d]pyrimidine as the directing group. A variety of monoacyloxylated pyrrolo[2,3-d]pyrimidine derivatives can be achieved by switching the solvents under mild conditions, and they can be further modified and exhibit various biological activities.

Graphical abstract: Pd-Catalyzed solvent-controlled site-selective arene C–H monoacyloxylation of pyrrolo[2,3-d]pyrimidine derivatives

Supplementary files

Article information

Article type
Paper
Submitted
29 Jul 2021
Accepted
13 Sep 2021
First published
14 Sep 2021

Org. Biomol. Chem., 2021,19, 8591-8596

Pd-Catalyzed solvent-controlled site-selective arene C–H monoacyloxylation of pyrrolo[2,3-d]pyrimidine derivatives

Z. Mao, M. Liu, H. Qian, Y. Jiang and X. Zhang, Org. Biomol. Chem., 2021, 19, 8591 DOI: 10.1039/D1OB01486B

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