Ye Zhang, Jingcheng Guo, Jinna Han, Xiangui Zhou, Wei Cao and Zhenqian Fu
Org. Biomol. Chem., 2021,19, 6412-6416
DOI:
10.1039/D1OB00981H,
Communication
Bifunctional squaramide-catalyzed nucleophilic addition of thiophenols to easily available β-silyl α,β-unsaturated carbonyl compounds has been successfully developed. A structurally diverse set of chiral α-mercaptosilanes was efficiently prepared in good to excellent yields with acceptable enantioselectivities. The reaction features mild reaction conditions, a broad substrate scope, and easy scale-up.
