Direct Sb–S cross-coupling of halostibines with thiols and disulfides at room temperature

Abstract

A facile and efficient protocol has been developed for preparing thiostibines via direct Sb–S cross-coupling of halostibines containing azastibocine frameworks with thiols under additive-free conditions. Additionally, a zinc(0)-mediated transformation of Sb–halogen bonds to Sb–S bonds by employing disulfides as the sulfur source is also described. These reactions proceed efficiently at room temperature, tolerate a wide range of functional groups, and can be scaled-up, delivering the corresponding coupling products in moderate to excellent yields.

Supplementary files

Article information

Article type
Communication
Submitted
17 May 2021
Accepted
15 Jun 2021
First published
15 Jun 2021

Org. Biomol. Chem., 2021, Accepted Manuscript

Direct Sb–S cross-coupling of halostibines with thiols and disulfides at room temperature

W. Li, S. Li, Z. Wang, C. Liu, Y. Ye, Y. Chen, Y. Xiong and J. lei, Org. Biomol. Chem., 2021, Accepted Manuscript , DOI: 10.1039/D1OB00959A

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