Issue 26, 2021

Recent developments in asymmetric Heck type cyclization reactions for constructions of complex molecules

Abstract

Intramolecular carbometallation-initiated asymmetric transformations are a general and powerful approach for the construction of carbo- and heterocyclic systems with one and more stereocenters. In addition, the newly developed multiple cascade reactions are an attractive strategy for increasing the molecular complexity in one step. In recent years, great progress has been made in this area with the use of various palladium and nickel complexes with P- and N-donor chiral ligands. This review highlights recent developments in intramolecular asymmetric Heck reactions, reductive Heck reactions and various types of cascade transformations (intramolecular Heck/Heck, Heck/nucleophilic trapping, Heck/Tsuji–Trost, Heck/Suzuki–Miyaura, Heck/Sonogashira, and Heck/carbonylation) in the synthesis of complex molecules over the past 5 years. A number of examples from before 2016 are included as background information. Particular attention is paid to the use of inexpensive nickel complexes as highly efficient catalysts for a number of asymmetric reactions considered here. A perspective on current challenges and potential future developments in the field of asymmetric Heck type cyclizations is also provided.

Graphical abstract: Recent developments in asymmetric Heck type cyclization reactions for constructions of complex molecules

Article information

Article type
Review Article
Submitted
14 Mar 2021
Accepted
18 May 2021
First published
11 Jun 2021

Org. Biomol. Chem., 2021,19, 5673-5701

Recent developments in asymmetric Heck type cyclization reactions for constructions of complex molecules

A. N. Reznikov, M. A. Ashatkina and Y. N. Klimochkin, Org. Biomol. Chem., 2021, 19, 5673 DOI: 10.1039/D1OB00496D

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