Matsuda–Heck arylation of itaconates: a versatile approach to heterocycles from a renewable resource†
Abstract
Itaconic acid esters and hemiesters undergo Pd-catalyzed coupling reactions with arene diazonium salts in high to excellent yields. The coupling products of ortho-nitro arene diazonium salts can be converted in one or two steps to benzazepine-2-ones.
- This article is part of the themed collection: Synthetic methodology in OBC