Direct C–H aminocarbonylation of N-heteroarenes with isocyanides under transition metal-free conditions

A C–C bond forming amide synthesis through direct C–H aminocarbonylation of N-heteroarenes with isocyanides was developed. The reaction was mediated by an inorganic persulfate salt under transition metal-free conditions. Mechanistic studies suggested a radical pathway for this reaction without the participation of H₂O and O₂. This method also showed merits of substrate availability, easy operation and atom economy. It provided an efficient route for straightforward synthesis of N-heteroaryl amides.