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Issue 21, 2021
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Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones

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Abstract

This review focuses on the synthesis of 3-hydroxyisoindolinones, and their application as substrates in stereoselective catalytic transformations reported from 2010 to date. These compounds have attracted much attention among synthetic chemists, as they are integral structural parts of a number of natural products and biologically active compounds. The first part of this review covers methods based on electrochemical, photochemical, and thermal reactions for the synthesis of 3-hydroxyisoindolinones. The second part focuses on their employment as substrates in transition metal-catalyzed and organocatalyzed stereoselective transformations for the preparation of chiral 3-substituted isoindolinone derivatives.

Graphical abstract: Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones

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Article information


Submitted
28 Jan 2021
Accepted
04 May 2021
First published
06 May 2021

Org. Biomol. Chem., 2021,19, 4637-4651
Article type
Review Article

Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones

N. Topolovčan and M. Gredičak, Org. Biomol. Chem., 2021, 19, 4637
DOI: 10.1039/D1OB00164G

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