Enantioselective fluorination of 3-indolinone-2-carboxylates with NFSI catalyzed by chiral bisoxazolines†
B.
Sridhar 
c
and
B. V.
Subba Reddy
*ab
c
and
B. V.
Subba Reddy
*ab
Abstract
A chiral Cu(I)–bisoxazoline complex catalyzed enantioselective electrophilic fluorination of 3-indolinone-2-carboxylates with NFSI has been accomplished to produce chiral 2-fluoro-3-indolinone-2-carboxylates in good yields with excellent enantioselectivities. This is the first report on the enantioselective fluorination of 2-substituted 3-indolinones using a chiral Cu(I)–bisoxazoline complex.
- This article is part of the themed collection: Synthetic methodology in OBC
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