Issue 21, 2021

An iodine-mediated new avenue to sulfonylation employing N-hydroxy aryl sulfonamide as a sulfonylating agent

Abstract

A novel and highly efficient I2/K2CO3 mediated regioselective sulfonylation of thiophenols, aryl acetylenic acid and aromatic alkynes with N-hydroxy sulfonamide has been developed. N-hydroxy sulfonamide has been used for the first time for the synthesis of these sulfones. The scope and versatility of the reaction has been demonstrated by the regio- and stereoselective synthesis of different analogs of sulfones with various structural features.

Graphical abstract: An iodine-mediated new avenue to sulfonylation employing N-hydroxy aryl sulfonamide as a sulfonylating agent

Supplementary files

Article information

Article type
Paper
Submitted
07 Jan 2021
Accepted
12 Apr 2021
First published
12 Apr 2021

Org. Biomol. Chem., 2021,19, 4760-4767

An iodine-mediated new avenue to sulfonylation employing N-hydroxy aryl sulfonamide as a sulfonylating agent

D. S. Raghuvanshi and N. Verma, Org. Biomol. Chem., 2021, 19, 4760 DOI: 10.1039/D1OB00036E

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