Issue 5, 2021

Modern approaches towards the synthesis of geminal difluoroalkyl groups

Abstract

This review will cover the importance of and most recent approaches toward geminal difluoroalkyl groups. Transition metal-mediated, photochemical, organocatalytic, and other methods as well as their mechanistic implications will be discussed, with special emphasis on applications to biologically-relevant compounds.

Graphical abstract: Modern approaches towards the synthesis of geminal difluoroalkyl groups

Article information

Article type
Review Article
Submitted
27 Nov 2020
Accepted
25 Dec 2020
First published
06 Jan 2021

Org. Biomol. Chem., 2021,19, 947-964

Modern approaches towards the synthesis of geminal difluoroalkyl groups

D. R. Carvalho and A. H. Christian, Org. Biomol. Chem., 2021, 19, 947 DOI: 10.1039/D0OB02374D

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