A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

Silvia Anselmi; Siyu Liu; Seong-Heun Kim; Sarah M. Barry; Thomas S. Moody; Daniele Castagnolo

doi:10.1039/D0OB01966F

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent†

Silvia Anselmi,

^a Siyu Liu,

^a Seong-Heun Kim,

^a Sarah M. Barry,

^b Thomas S. Moody

*^cd and Daniele Castagnolo

*^a

Author affiliations

* Corresponding authors

^a School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London, UK
E-mail: daniele.castagnolo@kcl.ac.uk

^b Department of Chemistry, Faculty of Natural & Mathematical Sciences, King's College London, Britannia House, 7 Trinity Street, London, UK

^c Almac Sciences, Department of Biocatalysis & Isotope Chemistry, 20 Seagoe Industrial Estate, Craigavon, UK
E-mail: tom.moody@almacgroup.com

^d Arran Chemical Company Limited, Unit 1 Monksland Industrial Estate, Athlone, Co. Roscommon, Ireland

Abstract

A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.

This article is part of the themed collections: Biocatalysis: A cross-journal collection and Catalysis & biocatalysis in OBC

Download options Please wait...

Supplementary files

Supplementary information PDF (2704K)

Article information

DOI: https://doi.org/10.1039/D0OB01966F
Article type: Communication
Submitted: 24 Sep 2020
Accepted: 05 Nov 2020
First published: 06 Nov 2020

Download Citation

Org. Biomol. Chem., 2021,19, 156-161

Permissions

Request permissions

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

S. Anselmi, S. Liu, S. Kim, S. M. Barry, T. S. Moody and D. Castagnolo, Org. Biomol. Chem., 2021, 19, 156 DOI: 10.1039/D0OB01966F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic & Biomolecular Chemistry

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

Social activity

Search articles by author

Spotlight

Advertisements