Reframing primary alkyl amines as aliphatic building blocks
While primary aliphatic amines are ubiquitous in natural products, they are traditionally considered inert to substitution chemistry. This review highlights historical and recent advances in the field of aliphatic deamination chemistry which demonstrate these moieties can be harnessed as valuable C(sp3) synthons. Cross-coupling and photocatalyzed transformations proceeding through polar and radical mechanisms are compared with oxidative deamination and other transition metal catalyzed reactions.
- This article is part of the themed collections: 2021 Organic & Biomolecular Chemistry HOT article collection and Synthetic methodology in OBC