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Issue 13, 2021

Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection

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Abstract

The control of COVID-19 across the world requires the formation of a range of interventions including vaccines to elicit an immune response and immunomodulatory or antiviral therapeutics. Here, we demonstrate the nanoparticle formulation of a highly insoluble drug compound, niclosamide, with known anti SARS-CoV-2 activity as a cheap and scalable long-acting injectable antiviral candidate.

Graphical abstract: Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection

Supplementary files

Article information


Submitted
16 Jan 2021
Accepted
10 Mar 2021
First published
20 Mar 2021

This article is Open Access

Nanoscale, 2021,13, 6410-6416
Article type
Communication

Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection

J. J. Hobson, A. C. Savage, A. B. Dwyer, C. Unsworth, J. Massam, U. Arshad, H. Pertinez, H. Box, L. Tatham, R. K. R. Rajoli, M. Neary, J. Sharp, A. Valentijn, C. David, P. Curley, N. J. Liptrott, T. O. McDonald, A. Owen and S. P. Rannard, Nanoscale, 2021, 13, 6410 DOI: 10.1039/D1NR00309G

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