Issue 7, 2021

Hierarchical approach for the rational construction of helix-containing nanofibrils using α,β-peptides

Abstract

The rational design of novel self-assembled nanomaterials based on peptides remains a great challenge in modern chemistry. A hierarchical approach for the construction of nanofibrils based on α,β-peptide foldamers is proposed. The incorporation of a helix-promoting trans-(1S,2S)-2-aminocyclopentanecarboxylic acid residue in the outer positions of the model coiled-coil peptide led to its increased conformational stability, which was established consistently by the results of CD, NMR and FT-IR spectroscopy. The designed oligomerization state in the solution of the studied peptides was confirmed using analytical ultracentrifugation. Moreover, the cyclopentane side chain allowed additional interactions between coiled-coil-like structures to direct the self-assembly process towards the formation of well-defined nanofibrils, as observed using AFM and TEM techniques.

Graphical abstract: Hierarchical approach for the rational construction of helix-containing nanofibrils using α,β-peptides

Supplementary files

Article information

Article type
Paper
Submitted
06 Jun 2020
Accepted
04 Jan 2021
First published
13 Jan 2021

Nanoscale, 2021,13, 4000-4015

Hierarchical approach for the rational construction of helix-containing nanofibrils using α,β-peptides

M. Szefczyk, N. Szulc, M. Gąsior-Głogowska, A. Modrak-Wójcik, A. Bzowska, W. Majstrzyk, M. Taube, M. Kozak, T. Gotszalk, E. Rudzińska-Szostak and Ł. Berlicki, Nanoscale, 2021, 13, 4000 DOI: 10.1039/D0NR04313C

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