Issue 9, 2021

Bottromycins - biosynthesis, synthesis and activity


Covering: 1950s up to the end of 2020

Bottromycins are a class of macrocyclic peptide natural products that are produced by several Streptomyces species and possess promising antibacterial activity against clinically relevant multidrug-resistant pathogens. They belong to the ribosomally synthesised and post-translationally modified peptide (RiPP) superfamily of natural products. The structure contains a unique four-amino acid macrocycle formed via a rare amidine linkage, C-methylation and a D-amino acid. This review covers all aspects of bottromycin research with a focus on recent years (2009–2020), in which major advances in total synthesis and understanding of bottromycin biosynthesis were achieved.

Graphical abstract: Bottromycins - biosynthesis, synthesis and activity

Article information

Article type
Review Article
16 Dec 2020
First published
23 Feb 2021
This article is Open Access
Creative Commons BY license

Nat. Prod. Rep., 2021,38, 1659-1683

Bottromycins - biosynthesis, synthesis and activity

L. Franz, U. Kazmaier, A. W. Truman and J. Koehnke, Nat. Prod. Rep., 2021, 38, 1659 DOI: 10.1039/D0NP00097C

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