Laura Franz, Uli Kazmaier, Andrew W. Truman and Jesko Koehnke
Nat. Prod. Rep., 2021,38, 1659-1683
DOI:
10.1039/D0NP00097C,
Review Article
Covering: 1950s up to the end of 2020
Bottromycins are a class of macrocyclic peptide natural products that are produced by several Streptomyces species and possess promising antibacterial activity against clinically relevant multidrug-resistant pathogens. They belong to the ribosomally synthesised and post-translationally modified peptide (RiPP) superfamily of natural products. The structure contains a unique four-amino acid macrocycle formed via a rare amidine linkage, C-methylation and a D-amino acid. This review covers all aspects of bottromycin research with a focus on recent years (2009–2020), in which major advances in total synthesis and understanding of bottromycin biosynthesis were achieved.