Issue 4, 2021

Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota

Abstract

Covering: up to September 2020

Mushroom-forming fungi of the division Basidiomycota have traditionally been recognised as prolific producers of structurally diverse and often bioactive secondary metabolites, using the methods of chemistry for research. Over the past decade, -omics technologies were applied on these fungi, and sophisticated heterologous gene expression platforms emerged, which have boosted research into the genetic and biochemical basis of the biosyntheses. This review provides an overview on experimentally confirmed natural product biosyntheses of basidiomycete polyketides, amino acid-derived products, terpenoids, and volatiles. We also present challenges and solutions particular to natural product research with these fungi. 222 references are cited.

Graphical abstract: Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota

Article information

Article type
Review Article
Submitted
05 Oct 2020
First published
06 Jan 2021

Nat. Prod. Rep., 2021,38, 702-722

Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota

M. Gressler, N. A. Löhr, T. Schäfer, S. Lawrinowitz, P. S. Seibold and D. Hoffmeister, Nat. Prod. Rep., 2021, 38, 702 DOI: 10.1039/D0NP00077A

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