Issue 4, 2021

Triptolide: reflections on two decades of research and prospects for the future

Abstract

Covering: 2000 to 2020

Triptolide is a bioactive diterpene triepoxide isolated from Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have been used as anti-inflammatory and immunosuppressive remedies for centuries. Although triptolide and its analogs exhibit potent bioactivities against various cancers, and inflammatory and autoimmune diseases, none of them has been approved to be used in the clinic. This review highlights advances in material sourcing, molecular mechanisms, clinical progress and new drug design strategies for triptolide over the past two decades, along with some prospects for the future course of development of triptolide.

Graphical abstract: Triptolide: reflections on two decades of research and prospects for the future

Article information

Article type
Review Article
Submitted
26 Jul 2020
First published
04 Nov 2020

Nat. Prod. Rep., 2021,38, 843-860

Triptolide: reflections on two decades of research and prospects for the future

L. Tong, Q. Zhao, E. Datan, G. Lin, I. Minn, M. G. Pomper, B. Yu, D. Romo, Q. He and J. O. Liu, Nat. Prod. Rep., 2021, 38, 843 DOI: 10.1039/D0NP00054J

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