Issue 34, 2021
From the journal:

New Journal of Chemistry

Laser-induced switching of the biological activity of phosphonate molecules†

Ilya Kolesnikov, ORCID logo a   Anastasia Khokhlova,b   Dmitry Pankin,a   Anna Pilip,c   Anastasia Egorova, ORCID logo c   Vladislav Zigel,c   Maxim Gureev,d   Gerd Leuchsef  and  Alina Manshina ORCID logo *b  

* Corresponding authors

a Center for Optical and Laser Materials Research, St. Petersburg State University, Uljanovskaya 5, St. Petersburg, Russia

b Institute of Chemistry, St. Petersburg State University, Universitetskii pr. 26, St. Petersburg, Russia
E-mail: a.manshina@spbu.ru

c St. Petersburg Federal Research Center of the Russian Academy of Sciences (SPC RAS), Scientific Research Centre for Ecological Safety of the Russian Academy of Sciences, 18,, Korpusnaya st, St. Petersburg, Russia

d I. M. Sechenov First Moscow State Medical University, Trubetskaya st. 8/2, Moscow, Russian Federation

e Max Planck Institute for the Science of Light, Staudtstr. 2, Erlangen 91058, Germany

f Institute of Applied Physics of the Russian Academy of Sciences, 46 Ul’yanov Street, Nizhny Novgorod 603950, Russia

Abstract

Butyrylcholinesterase inhibition and its enhancement as a result of laser irradiation are demonstrated for the first time for a series of phosphorylated arylaminomalonates. The effect of substituents in the phenyl group on butyrylcholinesterase inhibition and its laser-activated enhancement is revealed experimentally and confirmed by molecular dynamics and docking modelling.

Graphical abstract: Laser-induced switching of the biological activity of phosphonate molecules

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Article information

DOI
https://doi.org/10.1039/D1NJ02487F
Article type
Communication
Submitted
20 May 2021
Accepted
09 Aug 2021
First published
09 Aug 2021

New J. Chem., 2021,45, 15195-15199

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Laser-induced switching of the biological activity of phosphonate molecules

I. Kolesnikov, A. Khokhlova, D. Pankin, A. Pilip, A. Egorova, V. Zigel, M. Gureev, G. Leuchs and A. Manshina, New J. Chem., 2021, 45, 15195 DOI: 10.1039/D1NJ02487F

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