Palladium-catalyzed regioselective direct C–H bond alkoxycarbonylation of 2-arylimidazo[1,2-a]pyridines

Abstract

A palladium-catalyzed practical and efficient method to access alkoxycarbonylated imidazo[1,2-a]pyridines at the C-3 position has been developed based on the association of W(CO)₆ as a safe and easy-to-handle CO surrogate and related alcohols. Through this synthetic strategy, a wide range of alkoxycarbonylated imidazo[1,2-a]pyridines with moderate to high yields have been prepared, which are important structural motifs in pharmaceutical products.