Issue 7, 2021

Protein-, polymer-, and silica-based luminescent nanomaterial probes for super resolution microscopy: a review

Abstract

Super resolution microscopy was developed to overcome the Abbe diffraction limit, which effects conventional optical microscopy, in order to study the smaller components of biological systems. In recent years nanomaterials have been explored as luminescent probes for super resolution microscopy, as many have advantages over traditional fluorescent dye molecules. This review will summarize several different types of nanomaterial probes, covering quantum dots, carbon dots, and dye doped nanoparticles. For the purposes of this review the term “nanoparticle” will be limited to polymer-based, protein-based, and silica-based nanoparticles, including core–shell structured nanoparticles. Luminescent nanomaterials have shown promise as super-resolution probes, and continued research in this area will yield new advances in both materials science and biochemical microscopy at the nanometer scale.

Graphical abstract: Protein-, polymer-, and silica-based luminescent nanomaterial probes for super resolution microscopy: a review

Article information

Article type
Review Article
Submitted
20 Nov 2020
Accepted
15 Feb 2021
First published
22 Feb 2021
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2021,3, 1853-1864

Protein-, polymer-, and silica-based luminescent nanomaterial probes for super resolution microscopy: a review

S. Thompson and D. Pappas, Nanoscale Adv., 2021, 3, 1853 DOI: 10.1039/D0NA00971G

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