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Issue 4, 2021
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A review on the cytotoxicity of graphene quantum dots: from experiment to simulation

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Abstract

Graphene quantum dots (GQDs) generate intrinsic fluorescence and improve the aqueous stability of graphene oxide (GO) while maintaining wide chemical adaptability and high adsorption capacity. Despite GO's remarkable advantages in bio-imaging, bio-sensing, and other biomedical applications, many experiments and simulations have focused on the biosafety of GQDs. Here, we review the findings on the biosafety of GQDs from experiments; then, we review the results from simulated interactions with biological membranes, DNA molecules, and proteins; finally, we examine the intersection between experiments and simulations. The biosafety results from simulations are explained in detail. Based on the literature and our experiments, we also discuss the trends toward GQDs with better biosafety.

Graphical abstract: A review on the cytotoxicity of graphene quantum dots: from experiment to simulation

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Article information


Submitted
28 Oct 2020
Accepted
25 Dec 2020
First published
26 Dec 2020

This article is Open Access

Nanoscale Adv., 2021,3, 904-917
Article type
Review Article

A review on the cytotoxicity of graphene quantum dots: from experiment to simulation

L. Liang, X. Peng, F. Sun, Z. Kong and J. Shen, Nanoscale Adv., 2021, 3, 904
DOI: 10.1039/D0NA00904K

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    [Original citation] - Published by The Royal Society of Chemistry.

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