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Issue 5, 2021
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Nanoparticles and bioorthogonal chemistry joining forces for improved biomedical applications

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Abstract

Bioorthogonal chemistry comprises chemical reactions that can take place inside complex biological environments, providing outstanding tools for the investigation and elucidation of biological processes. Its use in combination with nanotechnology can lead to further developments in diverse areas of biomedicine, such as molecular bioimaging, targeted delivery, in situ drug activation, study of cell–nanomaterial interactions, biosensing, etc. Here, we summarise the recent efforts to bring together the unique properties of nanoparticles and the remarkable features of bioorthogonal reactions to create a toolbox of new or improved biomedical applications. We show how, by joining forces, bioorthogonal chemistry and nanotechnology can overcome some of the key current limitations in the field of nanomedicine, providing better, faster and more sensitive nanoparticle-based bioimaging and biosensing techniques, as well as therapeutic nanoplatforms with superior efficacy.

Graphical abstract: Nanoparticles and bioorthogonal chemistry joining forces for improved biomedical applications

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Article information


Submitted
19 Oct 2020
Accepted
21 Jan 2021
First published
21 Jan 2021

This article is Open Access

Nanoscale Adv., 2021,3, 1261-1292
Article type
Review Article

Nanoparticles and bioorthogonal chemistry joining forces for improved biomedical applications

J. Idiago-López, E. Moreno-Antolín, J. M. de la Fuente and R. M. Fratila, Nanoscale Adv., 2021, 3, 1261
DOI: 10.1039/D0NA00873G

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    [Original citation] - Published by The Royal Society of Chemistry.

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