The robust NMR toolbox for metabolomics

Kousik Chandra; Samah Al-Harthi; Fatimah Almulhim; Abdul-Hamid Emwas; Łukasz Jaremko; Mariusz Jaremko

doi:10.1039/D1MO00118C

The robust NMR toolbox for metabolomics†

Kousik Chandra,

^a Samah Al-Harthi,

^a Fatimah Almulhim,^a Abdul-Hamid Emwas,^b Łukasz Jaremko*^a and Mariusz Jaremko

*^a

Author affiliations

* Corresponding authors

^a Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
E-mail: Mariusz.jaremko@kaust.edu.sa

^b Core Laboratories, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia

Abstract

Here, we implemented and validated a suite of selective and non-selective CPMG-filtered 1D and 2D TOCSY/HSQC experiments for metabolomics research. They facilitated the unambiguous identification of metabolites embedded in broad lipid and protein signals. The 2D spectra improved non-targeted analysis by removing the background broad signals of macromolecules.

Molecular Omics

The robust NMR toolbox for metabolomics†

Abstract

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