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Genetic and structural analyses of ssRNA viruses pave the way for the discovery of novel antiviral pharmacological targets

Abstract

In the era of big data and artificial intelligence a lot of new discoveries have influenced the field of antiviral drug design and pharmacophore identification. Viruses have always been a thread to societies in terms of public health and economic stability. Viruses not only affect humans but also livestock and agriculture with a direct impact on food safety, economy and environmental imprint. Most recently with the pandemic of COVID-19 it was made clear that a single virus can have a devastating impact on global wellbeing and economy. In this direction, there is an emerging need for the identification of promising pharmacological targets in viruses. Herein, an effort has been made to discuss current knowledge, state of the art applications and future implications for the main pharmacological targets of single stranded RNA viruses.

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Article information


Submitted
01 Dec 2020
Accepted
18 Feb 2021
First published
19 Feb 2021

Mol. Omics, 2021, Accepted Manuscript
Article type
Review Article

Genetic and structural analyses of ssRNA viruses pave the way for the discovery of novel antiviral pharmacological targets

D. Vlachakis, Mol. Omics, 2021, Accepted Manuscript , DOI: 10.1039/D0MO00173B

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