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Issue 10, 2021
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Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications

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Abstract

Membranes play a crucial role in many microfluidic systems, enabling versatile applications in highly diverse research fields. However, the tight and robust integration of membranes into microfluidic systems requires complex fabrication processes. Most integration approaches, so far, rely on polydimethylsiloxane (PDMS) as base material for the microfluidic chips. Several limitations of PDMS have resulted in the transition of many microfluidic approaches to PDMS-free systems using alternative materials such as thermoplastics. To integrate membranes in those PDMS-free systems, novel alternative approaches are required. This review provides an introduction into microfluidic systems applying membrane technology for analytical systems and organ-on-chip as well as a comprehensive overview of methods for the integration of membranes into PDMS-free systems. The overview and examples will provide a valuable resource and starting point for any researcher that is aiming at implementing membranes in microfluidic systems without using PDMS.

Graphical abstract: Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications

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Article information


Submitted
09 Mar 2021
Accepted
24 Apr 2021
First published
26 Apr 2021

Lab Chip, 2021,21, 1866-1885
Article type
Critical Review

Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications

S. Schneider, D. Gruner, A. Richter and P. Loskill, Lab Chip, 2021, 21, 1866
DOI: 10.1039/D1LC00188D

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