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Issue 5, 2021
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Origami paper-based sample preconcentration using sequentially driven ion concentration polarization

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Abstract

Ion concentration polarization (ICP) is one of the preconcentration techniques which can acquire a high preconcentration factor. Still, the main hurdles of ICP are its instability and low efficiency under physiological conditions with high ionic strength and abundant biomolecules. Here, we suggested a sequentially driven ICP process, which enhanced the electrokinetic force required for preconcentration, enabling enrichment of highly ionic raw samples without increasing the electric field. We acquired a 13-fold preconcentration factor (PF) in human serum using a paper-based origami structure consisting of multiple layers for three-dimensional sequential ICP (3D seq-ICP). Moreover, we demonstrated a paper-based enzyme-linked immunosorbent assay (ELISA) by 3D seq-ICP using tau protein, showing a 6-fold increase in ELISA signals.

Graphical abstract: Origami paper-based sample preconcentration using sequentially driven ion concentration polarization

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Supplementary files

Article information


Submitted
14 Oct 2020
Accepted
16 Jan 2021
First published
18 Jan 2021

Lab Chip, 2021,21, 867-874
Article type
Paper

Origami paper-based sample preconcentration using sequentially driven ion concentration polarization

J. Lee, Y. K. Yoo, D. Lee, C. Kim, K. H. Kim, S. Lee, S. Kwak, J. Y. Kang, H. Kim, D. S. Yoon, D. Hur and J. H. Lee, Lab Chip, 2021, 21, 867 DOI: 10.1039/D0LC01032D

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