Issue 8, 2021
From the journal:

Green Chemistry

Eco-friendly construction of spiroquinazolin-2-(thi)ones and quinolin-(thio)ureas via Fe(iii)-catalyzed multi-component domino double [4 + 2] annulations†

Zhentao Pan,a   Shuaijun Shi,a   Xuancheng Yang,a   Xuqiong Xiao, ORCID logo b   Wangqin Zhang,c   Shiliang Wangc  and  Yongmin Ma ORCID logo *a  

* Corresponding authors

a Institute of Advanced Studies and School of Pharmaceutical and Chemical Engineering, Taizhou University, 1139 Shifu Avenue Taizhou, People's Republic of China
E-mail: yongmin.ma@tzc.edu.cn

b Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, No. 2318 Yuhangtang Rd. Hangzhou, P R China

c College of Pharmaceutical Sciences, Zhejiang University of Technology China and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. of China

Abstract

An unprecedented eco-friendly multi-component domino approach for the synthesis of novel spiroquinazolin-2-(thi)ones and quinolin-(thio)ureas is described. The protocol proceeds via domino double [4 + 2] annulations and features an eco-benign catalyst and solvent, simple starting materials, high atom-economy, H2O as the sole by-product and a simple work-up procedure.

Graphical abstract: Eco-friendly construction of spiroquinazolin-2-(thi)ones and quinolin-(thio)ureas via Fe(iii)-catalyzed multi-component domino double [4 + 2] annulations

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Article information

DOI
https://doi.org/10.1039/D1GC00889G
Article type
Communication
Submitted
11 Mar 2021
Accepted
25 Mar 2021
First published
26 Mar 2021

Green Chem., 2021,23, 2944-2949

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Eco-friendly construction of spiroquinazolin-2-(thi)ones and quinolin-(thio)ureas via Fe(III)-catalyzed multi-component domino double [4 + 2] annulations

Z. Pan, S. Shi, X. Yang, X. Xiao, W. Zhang, S. Wang and Y. Ma, Green Chem., 2021, 23, 2944 DOI: 10.1039/D1GC00889G

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