Photoredox-catalyzed hydroxydifluoroacetylation of alkenes with FSO2CF2CO2Me and H2O: simple synthesis of CF2CO2Me-containing alcohols and difluorolactones

Abstract

Photoredox-catalyzed hydroxydifluoroacetylation of alkenes with FSO₂CF₂CO₂Me and H₂O is presented. In this reaction, –CF₂CO₂Me and –OH groups are simultaneously introduced into the CC bond of the alkenes using fac-[Ir(ppy)₃] as the photocatalyst under visible light irradiation giving CF₂CO₂Me-containing alcohols and/or difluorolactones in high yields with high regioselectivity under mild conditions.