Issue 24, 2021

A low molecular weight brown algae Laminaria japonica glycan modulation of gut microbiota and body weight in mice

Abstract

Brown algae glycan from Laminaria japonica (LJNP) is a heterogeneous glycan with two apparent molecular weights of 1.1 and 37.3 kDa, and is mainly composed of α β-glucan and a few fucosyl residues. To explore the regulation of gut microbiota and the host, LJNP and 2′-fucosyllactose (2′FL) were compared to investigate their effect on mice via oral administration. Using metagenomic and metabolomic analyses, we found that 2′FL mainly relied on Adlercreutzia equolifaciens and Akkermansia muciniphila to improve gut amino acid and bile acid metabolism, whereas LJNP mainly drove Bacteroides vulgatus and Bacteroides uniformis to regulate gut amino acid metabolism and glycometabolism. Moreover, LJNP showed a weight loss effect and better protection of the intestinal barrier than 2′FL. We further employed LJNP and 2′FL on a germ-free mice model. Interestingly, the body weight management was not microbiome mediated. This study showed that LJNP can ameliorate the intestinal barrier through modulation of the gut microbiota, maintain the blood glucose level, and regulate body weight and the antioxidant function. Although the benefits of LJNP on host health were partly revealed, mechanisms such as the weight loss effect require further study.

Graphical abstract: A low molecular weight brown algae Laminaria japonica glycan modulation of gut microbiota and body weight in mice

Supplementary files

Article information

Article type
Paper
Submitted
10 Sep 2021
Accepted
08 Nov 2021
First published
09 Nov 2021

Food Funct., 2021,12, 12606-12620

A low molecular weight brown algae Laminaria japonica glycan modulation of gut microbiota and body weight in mice

Z. Jin, Z. Fang, Z. Pei, H. Wang, J. Zhu, Y. Lee, H. Zhang, J. Zhao, W. Lu and W. Chen, Food Funct., 2021, 12, 12606 DOI: 10.1039/D1FO03024H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements