Issue 17, 2021

Supplementation of egg white peptides on attenuating skin mechanical damage symptoms: a promising way to accelerate wound healing process

Abstract

Recent studies have indicated that active peptides can induce an improvement in wound repair. Herein, we evaluated egg white peptides (EWPs) as a nutritional supplement to improve mechanical skin damage in BALB/c mice. Two symmetrical circular full-thickness wounds were created with 5 mm biopsy punches in the skin of the mouse dorsal region, and EWPs (200, and 400 mg kg−1) were administrated by gavage for 14 days. We analyzed the EWPs for their in vivo and in vitro antioxidant capability, toxicity, and microscopy of skin wounds, and there was no cytotoxicity or in vivo toxicity. During the period of wound healing, EWPs could promote healthy cell migration, increase serum superoxide dismutase and catalase activities and accelerate the wound healing process in a time- and dose-dependent manner, whereas the levels of malondialdehyde and reactive oxygen species showed the opposite trend. After administration with 400 mg kg−1 EWPs for 10 days, the wound had almost healed. Meanwhile, EWPs significantly enhanced serum amino acids, particularly enhancing the content of Arg, Glu, Pro, Met, and Lys, which could provide sufficient nutrition in the wound healing process. The present study demonstrates that EWPs possess a positive potential to accelerate the wound healing process of mechanical skin damage at the cellular and animal level.

Graphical abstract: Supplementation of egg white peptides on attenuating skin mechanical damage symptoms: a promising way to accelerate wound healing process

Supplementary files

Article information

Article type
Paper
Submitted
17 May 2021
Accepted
05 Jul 2021
First published
08 Jul 2021

Food Funct., 2021,12, 7688-7698

Supplementation of egg white peptides on attenuating skin mechanical damage symptoms: a promising way to accelerate wound healing process

H. Ge, Y. Jiang, Z. Ning, Z. Hu, S. Ma, Y. Shao, J. Liu and T. Zhang, Food Funct., 2021, 12, 7688 DOI: 10.1039/D1FO01525G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements