Rapid and mild synthesis of Au–NHC complexes in a simple two-phase flow reactor

Abstract

We describe a simple two-phase flow reactor which allows for the rapid synthesis of several Au(I)–NHC complexes in high yields (>88%), under mild conditions, and with minimal workup. Translation of the standard weak base method to a two-phase flow reaction prevents the common problem of decomposition to Au(0). The reaction can be scaled up more than ten-fold without loss in conversion efficiency. An optional second stage allows for direct synthesis of Au(III)–NHC complexes, without isolation of the Au(I)–NHC intermediate, with a two-step isolated yield of 82%.