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Issue 18, 2021
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An unexpected in-solution instability of diiodido analogue of picoplatin complicates its biological characterization

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Abstract

Complex cis-[PtI2(NH3)(pic)] (1; pic = 2-methylpyridine), a diiodido analogue of clinically studied picoplatin (2), is unstable in solution, which is intriguingly connected with the release of its pic ligand. This observation complicates the biological testing of e.g. cytotoxicity in human cancer cells for 1.

Graphical abstract: An unexpected in-solution instability of diiodido analogue of picoplatin complicates its biological characterization

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Article information


Submitted
04 Mar 2021
Accepted
06 Apr 2021
First published
06 Apr 2021

Dalton Trans., 2021,50, 6071-6075
Article type
Communication

An unexpected in-solution instability of diiodido analogue of picoplatin complicates its biological characterization

P. Štarha, B. Drahoš and R. Herchel, Dalton Trans., 2021, 50, 6071
DOI: 10.1039/D1DT00740H

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