Jump to main content
Jump to site search

Issue 6, 2021
Previous Article Next Article

A T2ex MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach

Author affiliations

Abstract

pH is a critical parameter that has found unique application in magnetic resonance imaging (MRI) mapping acidity in tissues. This study reports a series of Dy-based MR probes that show innovative T2ex features, governed by proton catalyzed events. With an increase of pH from 5.5 to 8.0, the r2ex relaxivity increased dramatically, while the r1 relaxivity remained unchanged. The resulting r2ex/r1 allowed for concentration-independent and direct mapping of physiologically relevant pH ranges.

Graphical abstract: A T2ex MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach

Back to tab navigation

Supplementary files

Article information


Submitted
30 Oct 2020
Accepted
18 Jan 2021
First published
19 Jan 2021

Dalton Trans., 2021,50, 2014-2017
Article type
Communication

A T2ex MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach

Y. Zhang, K. Zhao, H. He, S. Wan, A. F. Martins, L. Zhang and K. Liu, Dalton Trans., 2021, 50, 2014
DOI: 10.1039/D0DT03734F

Social activity

Search articles by author

Spotlight

Advertisements