Issue 15, 2021

Hydroxyl radical is a significant player in oxidative DNA damage in vivo

Abstract

Recent publications have suggested that oxidative DNA damage mediated by hydroxyl radical (˙OH) is unimportant in vivo, and that carbonate anion radical (CO3˙) plays the key role. We examine these claims and summarize the evidence that ˙OH does play a key role as an important member of the reactive oxygen species (ROS) in vivo.

Graphical abstract: Hydroxyl radical is a significant player in oxidative DNA damage in vivo

Article information

Article type
Viewpoint
Submitted
13 Jan 2021
First published
15 Jun 2021

Chem. Soc. Rev., 2021,50, 8355-8360

Hydroxyl radical is a significant player in oxidative DNA damage in vivo

B. Halliwell, A. Adhikary, M. Dingfelder and M. Dizdaroglu, Chem. Soc. Rev., 2021, 50, 8355 DOI: 10.1039/D1CS00044F

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