Issue 6, 2021

Directing group migration strategy in transition-metal-catalysed direct C–H functionalization

Abstract

Very recently, directing group (DG) migration has emerged as a practical strategy for transition-metal-catalysed direct C–H activation, resulting in a highly atom-economical process and enabling the reusage of DG. Therefore, great progress has been made in developing multitasking DGs. In this tutorial review, we present the rapid advances of this novel strategy by analyzing and comparing the different types of migratable DGs (including N–O, N–C, N–N or O–C bond cleavage to trigger DG migration). The related mechanisms, as well as synthetic applications, are also mentioned.

Graphical abstract: Directing group migration strategy in transition-metal-catalysed direct C–H functionalization

Article information

Article type
Tutorial Review
Submitted
02 Sep 2020
First published
25 Jan 2021

Chem. Soc. Rev., 2021,50, 3677-3689

Directing group migration strategy in transition-metal-catalysed direct C–H functionalization

Y. Wu, C. Pi, Y. Wu and X. Cui, Chem. Soc. Rev., 2021, 50, 3677 DOI: 10.1039/D0CS00966K

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