Issue 92, 2021

Ir(iii)-Catalysed electrooxidative intramolecular dehydrogenative C–H/N–H coupling for the synthesis of N–H indoles

Abstract

Herein, an iridium(III)-catalysed electrooxidative intramolecular dehydrogenative C–H/N–H coupling of unprotected 2-alkenyl anilines is described. The developed method allows the synthesis of a variety of 3-substituted N–H indole scaffolds under undivided electrolytic conditions. Mechanistic studies suggest that the reaction proceeds through the electro-oxidation induced reductive elimination pathway.

Graphical abstract: Ir(iii)-Catalysed electrooxidative intramolecular dehydrogenative C–H/N–H coupling for the synthesis of N–H indoles

Supplementary files

Article information

Article type
Communication
Submitted
19 Oct 2021
Accepted
29 Oct 2021
First published
01 Nov 2021

Chem. Commun., 2021,57, 12309-12312

Ir(III)-Catalysed electrooxidative intramolecular dehydrogenative C–H/N–H coupling for the synthesis of N–H indoles

Y. Kim, D. Kim and S. Chang, Chem. Commun., 2021, 57, 12309 DOI: 10.1039/D1CC05882G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements