Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging

Haixiao Fang; Riri Shi; Ding Chen; Yunwei Qu; Qiong Wu; Xuekang Yang; Xiaomei Lu; Cheng-Wu Zhang; Lin Li; Kah-Leong Lim

doi:10.1039/D1CC04744B

Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging†

Haixiao Fang,^a Riri Shi,^a Ding Chen,^a Yunwei Qu,^a Qiong Wu,^a Xuekang Yang,^b Xiaomei Lu,^a Cheng-Wu Zhang,*^a Lin Li

*^ac and Kah-Leong Lim*^d

Author affiliations

* Corresponding authors

^a Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, P. R. China
E-mail: iamcwzhang@njtech.edu.cn, iamlli@njtech.edu.cn

^b Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, P. R. China

^c The Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen, 361005, P. R. China

^d Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, 302238, Singapore
E-mail: kahleong.lim@ntu.edu.sg

Abstract

MAO-A promotes the proliferation of human glioma cells. Herein, we report a series of MAO-A specific two-photon small molecular fluorescent probes (A1–5) based on an intramolecular charge transfer enhancing strategy. The activity of endogenous MAO-A can be selectively imaged using A3 as a representative probe in different biological samples including human glioma cells/tissues via two-photon fluorescence microscopy. The study provides new tools for the visual detection of glioma.

Chemical Communications

Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging†

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Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging

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