Issue 78, 2021

Homogeneous catalytic C(sp3)–H functionalization of gaseous alkanes


The conversion of light alkanes into bulk chemicals is becoming an important challenge as it effectively avoids the use of prefunctionalized alkylating reagents. The implementation of such processes is, however, hampered by their gaseous nature and low solubility, as well as the low reactivity of the C–H bonds. Efforts have been made to enable both polar and radical processes to activate these inert compounds. In addition, these methodologies also benefit significantly from the development of a suitable reactor technology that intensifies gas–liquid mass transfer. In this review, we critically highlight these developments, both from a conceptual and a practical point of view. The recent expansion of these mechanistically-different methods have enabled the use of various gaseous alkanes for the development of different bond-forming reactions, including C–C, C–B, C–N, C–Si and C–S bonds.

Graphical abstract: Homogeneous catalytic C(sp3)–H functionalization of gaseous alkanes

Article information

Article type
Feature Article
27 Jul 2021
01 Sep 2021
First published
01 Sep 2021
This article is Open Access
Creative Commons BY license

Chem. Commun., 2021,57, 9956-9967

Homogeneous catalytic C(sp3)–H functionalization of gaseous alkanes

A. Pulcinella, D. Mazzarella and T. Noël, Chem. Commun., 2021, 57, 9956 DOI: 10.1039/D1CC04073A

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