Issue 75, 2021
From the journal:

Chemical Communications

Screening of dicyanoisophorone-based probes for highly sensitive detection of viscosity changes in living cells and zebrafish†

Fanpeng Kong,‡*a   Ying Li,‡a   Xiao Li,a   Xiaoxiu Wang,a   Guanyu Fu,a   Qiuyue Zhaoa  and  Bo Tang ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, People's Republic of China
E-mail: kong-fanpeng@163.com, tangb@sdnu.edu.cn

Abstract

Herein, seven viscosity-sensitive probes were developed via simple structural modification of dicyanoisophorone (DCO)-derived dyes. Among them, DCO-5 significantly enhances (180-fold) the response signal in highly viscous aqueous media while showing insensitivity to polarity changes or pH variations, and enables the successful detection of viscosity changes in nystatin-treated HepG2 cells, PC 12 cells and zebrafish.

Graphical abstract: Screening of dicyanoisophorone-based probes for highly sensitive detection of viscosity changes in living cells and zebrafish

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Article information

DOI
https://doi.org/10.1039/D1CC03738B
Article type
Communication
Submitted
12 Jul 2021
Accepted
23 Aug 2021
First published
24 Aug 2021

Chem. Commun., 2021,57, 9554-9557

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Screening of dicyanoisophorone-based probes for highly sensitive detection of viscosity changes in living cells and zebrafish

F. Kong, Y. Li, X. Li, X. Wang, G. Fu, Q. Zhao and B. Tang, Chem. Commun., 2021, 57, 9554 DOI: 10.1039/D1CC03738B

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