Xiang Wu, Du Ding, Ying Zhang, Hua-Jie Jiang, Tao Wang and Li-Ping Zhao
Chem. Commun., 2021,57, 9680-9683
DOI:
10.1039/D1CC03568A,
Communication
We describe a catalytic asymmetric iminium ion cyclization reaction of simple 2-alkenylbenzaldimines using a BINOL-derived chiral N-triflyl phosphoramide. The corresponding 1-aminoindenes and tetracyclic 1-aminoindanes are formed in good yields and high enantioselectivities. Further, the chemical utility of the obtained enantiopure 1-aminoindene is demonstrated for the asymmetric synthesis of (S)-rasagiline.
