Issue 71, 2021
From the journal:

Chemical Communications

A pendant droplet-based sensor for the detection of acetylcholinesterase and its inhibitors†

Benyou Li,a   Yongxian Guo,b   Yifei Jiang, ORCID logo c   Jin-Ming Lin, ORCID logo d   Qiongzheng Hu ORCID logo *b  and  Li Yu ORCID logo *a  

* Corresponding authors

a Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of Education, Jinan 250100, P. R. China
E-mail: ylmlt@sdu.edu.cn

b School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, P. R. China
E-mail: huqz@sdas.org

c Department of Chemistry, University of Washington, Seattle, Washington 98195, USA

d Beijing Key Laboratory of Microanalytical Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China

Abstract

In this work, a pendant droplet-based sensor is developed for the rapid and label-free detection of acetylcholinesterase (AChE) and its inhibitors. The detection limit of AChE reaches 0.17 mU mL−1. The pIC50 values of AChE inhibitors such as neostigmine, rivastigmine and galantamine are determined to be 0.45 μM, 0.64 μM and 4.93 μM, respectively.

Graphical abstract: A pendant droplet-based sensor for the detection of acetylcholinesterase and its inhibitors

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Article information

DOI
https://doi.org/10.1039/D1CC03370K
Article type
Communication
Submitted
26 Jun 2021
Accepted
05 Aug 2021
First published
06 Aug 2021

Chem. Commun., 2021,57, 8909-8912

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A pendant droplet-based sensor for the detection of acetylcholinesterase and its inhibitors

B. Li, Y. Guo, Y. Jiang, J. Lin, Q. Hu and L. Yu, Chem. Commun., 2021, 57, 8909 DOI: 10.1039/D1CC03370K

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