Issue 63, 2021
From the journal:

Chemical Communications

Transformable upconversion metal–organic frameworks for near-infrared light-programmed chemotherapy†

Fang Wang,a   Zhen Li, ORCID logo b   Xiaobo Zhang,a   Rengan Luo,a   Hanlin Houa  and  Jianping Lei ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
E-mail: jpl@nju.edu.cn

b State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China

Abstract

A transformable upconversion MOF comprising a UCNP core and an azobenzene-based MOF shell is designed for NIR light-modulated chemotherapy. The dual Förster resonance energy transfers (FRETs) involved in this delivery system trigger the transformation of the MOF for drug release and prodrug activation, thus significantly inhibiting the tumor growth and metastasis.

Graphical abstract: Transformable upconversion metal–organic frameworks for near-infrared light-programmed chemotherapy

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Article information

DOI
https://doi.org/10.1039/D1CC02670D
Article type
Communication
Submitted
21 May 2021
Accepted
04 Jul 2021
First published
05 Jul 2021

Chem. Commun., 2021,57, 7826-7829

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Transformable upconversion metal–organic frameworks for near-infrared light-programmed chemotherapy

F. Wang, Z. Li, X. Zhang, R. Luo, H. Hou and J. Lei, Chem. Commun., 2021, 57, 7826 DOI: 10.1039/D1CC02670D

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