γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases

Jordi C. J. Hintzen; Yan Luo; Miriam R. B. Porzberg; Paul B. White; Jie Jian; Giordano Proietti; Jasmin Mecinović

doi:10.1039/D1CC02589A

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γ-Difluorolysine as a ¹⁹F NMR probe for histone lysine methyltransferases and acetyltransferases†

Jordi C. J. Hintzen,

‡^a Yan Luo,‡^ab Miriam R. B. Porzberg,

‡^a Paul B. White,‡^c Jie Jian,^a Giordano Proietti^a and Jasmin Mecinović

*^a

Author affiliations

* Corresponding authors

^a Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark
E-mail: mecinovic@sdu.dk
Tel: +45 6550 3603

^b College of Pharmacy & International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, Chongqing 402160, China

^c Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen 6525 AJ, The Netherlands

Abstract

Histone lysine methylation and acetylation are important posttranslational modifications that regulate gene expression in humans. Due to the interplay of these two modifications, new chemical methods to study lysine posttranslational modifications are highly desired. Here, we report the use of γ-difluorolysine as a lysine mimic and ¹⁹F NMR probe for examinations of histone methylation and acetylation.

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Article information

DOI: https://doi.org/10.1039/D1CC02589A
Article type: Communication
Submitted: 17 May 2021
Accepted: 10 Jun 2021
First published: 10 Jun 2021

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Chem. Commun., 2021,57, 6788-6791

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γ-Difluorolysine as a ¹⁹F NMR probe for histone lysine methyltransferases and acetyltransferases

J. C. J. Hintzen, Y. Luo, M. R. B. Porzberg, P. B. White, J. Jian, G. Proietti and J. Mecinović, Chem. Commun., 2021, 57, 6788 DOI: 10.1039/D1CC02589A

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Chemical Communications