Jump to main content
Jump to site search

Issue 46, 2021

The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4

Author affiliations

Abstract

pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.

Graphical abstract: The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4

Supplementary files

Article information


Submitted
06 Apr 2021
Accepted
04 May 2021
First published
05 May 2021

This article is Open Access

Chem. Commun., 2021,57, 5654-5657
Article type
Communication

The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4

X. Cai, S. Javor, B. H. Gan, T. Köhler and J. Reymond, Chem. Commun., 2021, 57, 5654 DOI: 10.1039/D1CC01838H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements